MAVENCLAD™ (cladribine tablets) │ EMD Serono
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Brain Lesions 1

Number of T1 Gd+ lesions over 96 weeks (secondary endpoint)2*

Brain Lesions 2

Number of active T2-weighted lesions over 96 weeks (secondary endpoint)2*

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Demonstrated reduction in ARR

Relapse-free rate

Demonstrated reduction in 3-month EDSS progression


See how MAVENCLAD achieved
a 57.6% relative reduction in ARR  over 96 weeks vs. placebo
(p<0.001, 0.14 vs. 0.33, respectively).

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See how MAVENCLAD allowed
79.7% of patients to remain relapse-free at 96 weeks
(vs. placebo, 79.7 vs. 60.9, respectively; p<0.001;
secondary endpoint).

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See how MAVENCLAD delivered
a 33% reduction in risk of disability
progression (EDSS) vs. placebo (p=0.02,
HR: 0.67, secondary endpoint).

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Footnotes and References

ARR=annualized relapse rate; EDSS=Expanded Disability Status Scale; Gd+=gadolinium-enhancing; MRI=magnetic resonance imaging 

* 96-week, phase III, multicentre, double-blind, placebo-controlled trial to evaluate the safety and efficacy of cladribine tablets in patients with relapsing-remitting multiple sclerosis. 1,326 patients were randomized (1:1:1) to receive a cumulative dose of cladribine tablets (3.5 mg/kg [n=433] or 5.25 mg/kg [n=456]) or placebo (n=437), in two treatment courses. The 5.25 mg/kg dosage regimen is not available.1

  1. MAVENCLAD™ Product Monograph. EMD Serono. November 2017.
  2. Giovannoni G, et al. A placebo-controlled trial of oral cladribine for relapsing multiple sclerosis. N Engl J Med 2010;362:416-26.

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